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Fig. 7 | Experimental Hematology & Oncology

Fig. 7

From: Heat-killed Prevotella intermedia promotes the progression of oral squamous cell carcinoma by inhibiting the expression of tumor suppressors and affecting the tumor microenvironment

Fig. 7

Effects of heat-killed P. intermedia on the transcriptomics of proinflammatory cytokines and chemokines in transplanted tumor model mice. a Top 20 upregulated pathways in the heat-killed P. intermedia group by using KEGG pathway enrichment analysis. The red triangle indicates OSCC-related top 1 proinflammatory signaling pathways. b Chord diagrams of upregulated genes and pathways. Red asterisks indicate important genes in the upregulated signaling pathway. c Heatmap of the chemokine activity pathway gene set in both groups. d Representative images of IL-17A, IL-6, and IL-23 IHC staining. The relative AOD of IHC staining was compared between the control and heat-killed P. intermedia groups. The data are shown as the mean ± SD and were analyzed by t test. **P < 0.01, ****P < 0.0001

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Experimental Hematology & Oncology

ISSN: 2162-3619

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