Fig. 2

Representative images of H&E and FISH staining of human normal or OSCC tissues. DAPI (blue). P. intermedia labeled with specific probes (yellow). a Normal oral mucosal epithelial surface, mucosal lamina propria, and muscle tissues. b Mucosal surface of OSCC, muscle tissues around OSCC, various differentiated OSCC tissues, low or high pattern of invasion (POI) OSCC tissues. c Fluorescence intensity difference of P. intermedia between normal and OSCC tissues. d Fluorescence area difference of P. intermedia between normal and OSCC tissues. Data were analyzed by t test. *P < 0.05, ****P < 0.0001